INDUCTION OF TOLERANCE TO SHEEP RED BLOOD CELLS

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Induction of Tolerance to Sheep Red Blood Cells

Adult mice injected with a sheep red blood cell hemolysate supernatant fraction were found to have a severely reduced responsiveness to subsequent immunization with sheep red blood cells. The induced unresponsiveness was found to be specific, as tested by reciprocal experiments involving horse and sheep erythrocyte preparations. The tolerogenic material did not appear to be immunogenic.

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ژورنال

عنوان ژورنال: Journal of Experimental Medicine

سال: 1972

ISSN: 1540-9538,0022-1007

DOI: 10.1084/jem.136.6.1666